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PRESCRIBING INFORMATION

FOR HEALTHCARE PROFESSIONALS

Ulcerative Colitis Risk Factors and Causes

Bringing the causes of ulcerative colitis to light.

Nobody knows what causes ulcerative colitis (UC). It affects males and females equally. Most people are diagnosed in their 20s and 30s, but it can occur at any age. An estimated half a million Americans suffer from UC.

UC may not be caused by stress, but many find that their anxiety over having the condition can worsen their symptoms. Another factor that may aggravate symptoms is food. While it's not clear what relationship food has to UC, some patients believe that certain foods act as a trigger.

But what exactly is UC? Most healthcare professionals think UC is a type of autoimmune reaction in which the immune system mistakes food, helpful bacteria and other materials in the colon for harmful invaders. The result? The immune system sends white blood cells to attack substances in the colon, which causes inflammation and other symptoms of UC.

Some possible risk factors for UC are:

Family history — up to 20 percent of people with UC have an immediate relative with UC.
Environmental factors — some research suggests that environmental factors, such as industrialization, sanitation and hygiene, or differences in access to specialized healthcare may be related to geographical differences in rates of UC.
Ethnicity — Caucasians have the highest risk. People of Jewish and European descent are 4-5 times as likely to have UC.

Your doctor is your best source of information for anything you don't understand about your disease, so don't hesitate to ask about any subject relating to your condition.

Bringing real answers to life.

While research continues to look for a cause and a cure, many advances have been made in treatments that help manage symptoms long term. APRISO's convenient once-daily extended-release formula has been shown to be effective in helping UC patients manage their symptoms and stay in remission for up to six months.

APRISO is a locally acting aminosalicylate indicated for the maintenance of remission of ulcerative colitis in patients 18 years and older. APRISO is contraindicated in patients with hypersensitivity to salicylates or aminosalicylates (sulfasalazine) or to any of the components of APRISO capsules. It is recommended that patients have an evaluation of renal function prior to initiation of APRISO therapy and periodically while on therapy. Exercise caution when using APRISO in patients with known renal dysfunction or a history of renal disease. There have been reports of hepatic failure in patients with pre–existing liver disease who have been administered mesalamine. Caution should be exercised when administering APRISO to patients with liver disease. The recommended dose of APRISO is four 0.375–g capsules once daily in the morning (1.5 g/day) with or without food. Because dissolution of the coating of APRISO granules depends on pH, APRISO should not be coadministered with antacids. Patients with phenylketonuria should be aware that APRISO contains aspartame, equivalent to 2.24 mg of phenylalanine per day. In 2 well–controlled clinical trials, the most common treatment–related adverse events occurring in at least 3% of adult patients taking 1.5 g/day of APRISO were headache (11% vs 8% for placebo), diarrhea (8% vs 7% for placebo), upper abdominal pain (5% vs 3% for placebo), nausea (4% vs 3% for placebo), nasopharyngitis (4% vs 3% for placebo), influenza and influenza–like illness (4% vs 4% for placebo), and sinusitis (3% vs 3% for placebo).

For complete Prescribing Information, please click here.